Abstract
Soft tissue deposits, also known as tumour deposits (TDs), have not been studied well
in head and neck squamous cell carcinoma (HNSCC) and are not included in any of the
staging systems or treatment guidelines. The aim of this systematic review was to
determine the prevalence and prognostic implications of TDs in patients with HNSCC.
This systematic review of the literature was conducted following the PRISMA guidelines.
The PubMed, Embase, and Scopus electronic databases were searched for relevant studies,
from inception to August 2022. Although 14 studies qualified for inclusion, only eight
were finally included in the review due to the considerable overlap of patients in
several studies. Data from 7127 patients were analysed. The pooled prevalence of TDs
was 21% (95% confidence interval (CI) 9–33%). The presence of TDs was adversely associated
with overall survival and disease-free survival, with hazard ratios of 2.08 (95% CI
1.60–2.70) and 2.56 (95% CI 1.97–3.32), respectively. TDs are detected in a significant
number of patients with HNSCC and adversely affect survival. Longitudinal prospective
studies are needed to evaluate the prognostic implications of TDs in HNSCC for their
potential role in cancer staging and adjuvant treatment planning.
Keywords
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Article info
Publication history
Published online: February 11, 2023
Accepted:
January 24,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
