Abstract
The objective of this study was to evaluate the accuracy and feasibility of intraoperative
frozen section analysis of samples harvested with a trephine drill from the bone resection
margins to identify malignancy. Thirty-five patients who were diagnosed with locally
advanced oral squamous cell carcinoma involving the mandible were included in this
study. After tumour resection, bone samples were collected from the resection margin
of the specimen using a trephine drill. Sampling yielded a cylindrical specimen of
bony tissue that included both cortical and cancellous areas. A second sample was
obtained from the area where bone invasion was evident; this was used as a positive
control. Frozen section analysis was performed intraoperatively to check for malignancy.
The sensitivity of this technique was found to be 81.8%, with specificity of 87.5%,
a positive predictive value of 75%, negative predictive value of 91.3%, and accuracy
of 85.7% when compared to standard histopathology as the gold standard. In conclusion,
the evaluation of bone margins using the trephine drill technique and frozen section
analysis proved to be fast and reliable.
Keywords
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Article info
Publication history
Published online: August 15, 2022
Accepted:
July 26,
2022
Identification
Copyright
© 2022 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
