Abstract
A systematic review based on the PRISMA guidelines was conducted to investigate and
compare treatment with hyaluronic acid (HA), corticosteroids, and blood products in
patients with temporomandibular joint osteoarthritis (TMJOA). The MEDLINE/PubMed,
Embase, and Cochrane Library databases were searched for articles published until
September 25, 2019. Articles met the inclusion criteria if they reported patients
with TMJOA, a comparison group, and a follow-up period of at least 6 months. The mean
and standard deviation for TMJ pain and maximum mouth opening (MMO) were reported.
Nine studies involving 443 patients were included. Injectables and Ringer’s lactate
solution or normal saline were reported to significantly improve TMJ pain and MMO.
Regarding TMJ pain, two studies showed a significant superiority of plasma rich in
growth factors (PRGF)/platelet-rich plasma (PRP) injections with or without arthrocentesis
over HA, but HA showed a significant improvement compared to corticosteroids. For
MMO, no injectable was found to be superior to Ringer’s lactate or a normal saline
control, but arthrocentesis + PRP resulted in MMO improvement compared to arthrocentesis
+ HA. Overall, all injectables in conjunction with arthrocentesis were efficient in
alleviating pain and improving MMO in TMJOA patients; however, a meta-analysis was
not possible due to heterogeneity across studies.
Key words
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Article info
Publication history
Published online: February 25, 2021
Accepted:
January 22,
2021
Identification
Copyright
© 2021 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
