Advertisement

Do sex hormone imbalances contribute to idiopathic condylar resorption?

  • M. Yuan
    Affiliations
    Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China
    Search for articles by this author
  • Q. Xie
    Affiliations
    Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China
    Search for articles by this author
  • P. Shen
    Correspondence
    Address: Pei Shen, Department of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China. Tel.: +86 21 23271699
    Affiliations
    Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China
    Search for articles by this author
  • C. Yang
    Correspondence
    Address: Chi Yang Yang, Department of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China. Tel.: +86 21 23271699
    Affiliations
    Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China
    Search for articles by this author
Published:February 23, 2021DOI:https://doi.org/10.1016/j.ijom.2021.01.017

      Abstract

      Idiopathic condylar resorption (ICR) is an aggressive form of temporomandibular joint disease that most frequently presents in adolescent girls during the pubertal growth spurt. Although numerous studies have indicated that the etiopathogenesis of ICR may be related to estrogen deficiency, the decisive role of estrogens remains controversial, and other sex hormone disturbances have not yet been investigated in this regard. Therefore, the aim of this study was to ascertain the role of serum estrogen levels and also the roles of other sex hormones in the pathogenesis of ICR. Ninety-four ICR patients and 324 disc displacement (DD) patients, of both sexes, were enrolled. Information on menstruation and serum levels of follicle-stimulating hormone, luteinizing hormone, prolactin, 17β-estradiol (E2), testosterone, and progesterone were recorded and analyzed. The results showed that female ICR patients had normal puberty onset, within the average age range. Use of oral contraceptives and other menstruation-regulating pharmaceuticals was similar in the two groups. Of note, neither serum E2 levels nor those of the other sex hormones differed significantly between female ICR and DD patients. However, male ICR patients had significantly increased serum testosterone levels (P = 0.002) and relatively higher E2 levels (P = 0.095) compared to DD patients. This study found that reduced serum E2 did not contribute to ICR; instead, systemic testosterone disturbances were found to be related to ICR.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to International Journal of Oral and Maxillofacial Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Posnick J.C.
        • Fantuzzo J.J.
        Idiopathic condylar resorption: current clinical perspectives.
        J Oral Maxillofac Surg. 2007; 65: 1617-1623https://doi.org/10.1016/j.joms.2007.03.026
        • Mehra P.
        • Wolford L.M.
        The Mitek mini anchor for TMJ disc repositioning: surgical technique and results.
        Int J Oral Maxillofac Surg. 2001; 30: 497-503https://doi.org/10.1054/ijom.2001.0163
        • Hatcher D.C.
        Progressive condylar resorption: pathologic processes and imaging considerations.
        Semin Orthod. 2013; 19: 97-105https://doi.org/10.1053/j.sodo.2012.11.005
        • Wolford L.M.
        Idiopathic condylar resorption of the temporomandibular joint in teenage girls (cheerleaders syndrome).
        Baylor Univ Med Cent Proc. 2001; 14: 246-252https://doi.org/10.1080/08998280.2001.11927772
        • Arnett G.W.
        • Milam S.B.
        • Gottesman L.
        Progressive mandibular retrusion—idiopathic condylar resorption. Part I.
        Am J Orthod Dentofacial Orthop. 1996; 110: 8-15https://doi.org/10.1016/S0889-5406(96)70081-1
        • Arnett G.W.
        • Milam S.B.
        • Gottesman L.
        Progressive mandibular retrusion—idiopathic condylar resorption. Part II.
        Am J Orthod Dentofacial Orthop. 1996; 110: 117-127https://doi.org/10.1016/S0889-5406(96)70099-9
        • Gunson M.J.
        • Arnett G.W.
        • Formby B.
        • Falzone C.
        • Mathur R.
        • Alexander C.
        Oral contraceptive pill use and abnormal menstrual cycles in women with severe condylar resorption: a case for low serum 17β-estradiol as a major factor in progressive condylar resorption.
        Am J Orthod Dentofacial Orthop. 2009; 136: 772-779https://doi.org/10.1016/j.ajodo.2009.07.011
        • Yang H.J.
        • Hwang S.J.
        Bone mineral density and mandibular advancement as contributing factors for postoperative relapse after orthognathic surgery in patients with preoperative idiopathic condylar resorption: a prospective study with preliminary 1-year follow-up.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120: 112-118https://doi.org/10.1016/j.oooo.2015.03.004
        • Alsabban L.
        • Amarista F.J.
        • Mercuri L.G.
        • Perez D.
        Idiopathic condylar resorption: a survey and review of the literature.
        J Oral Maxillofac Surg. 2018; 76: 2316.e1-2316.e13https://doi.org/10.1016/j.joms.2018.07.008
        • Feng C.
        • Ji P.
        • Luo P.
        • Xu J.
        Estrogen-mediated microRNA-101-3p expression represses hyaluronan synthase 2 in synovial fibroblasts from idiopathic condylar resorption patients.
        J Oral Maxillofac Surg. 2019; 77: 1582-1593https://doi.org/10.1016/j.joms.2019.02.032
        • Nicolielo L.F.P.
        • Jacobs R.
        • Ali Albdour E.
        • Hoste X.
        • Abeloos J.
        • Politis C.
        • Swennen G.
        Is oestrogen associated with mandibular condylar resorption? A systematic review.
        Int J Oral Maxillofac Surg. 2017; 46: 1394-1402https://doi.org/10.1016/j.ijom.2017.06.012
        • Shen P.
        • Xie Q.
        • Ma Z.
        • Abdelrehem A.
        • Zhang S.
        • Yang C.
        Yang’s classification of juvenile TMJ anterior disc displacement contributing to treatment protocols.
        Sci Rep. 2019; 9: 1-8https://doi.org/10.1038/s41598-019-42081-5
        • Diaz A.
        • Laufer M.R.
        • Breech L.L.
        Menstruation in girls and adolescents: using the menstrual cycle as a vital sign.
        Pediatrics. 2006; 118: 2245-2250https://doi.org/10.1542/peds.2006-2481
        • Wolford L.M.
        • Cardenas L.
        Idiopathic condylar resorption: diagnosis, treatment protocol, and outcomes.
        Am J Orthod Dentofacial Orthop. 1999; 116: 667-677https://doi.org/10.1016/S0889-5406(99)70203-9
        • Mitsimponas K.
        • Mehmet S.
        • Kennedy R.
        • Shakib K.
        Idiopathic condylar resorption.
        Br J Oral Maxillofac Surg. 2018; 56: 249-255https://doi.org/10.1016/j.bjoms.2018.02.016
        • Frank G.R.
        Role of estrogen and androgen in pubertal skeletal physiology.
        Med Pediatr Oncol. 2003; 41: 217-221https://doi.org/10.1002/mpo.10340
        • Landi N.
        • Lombardi I.
        • Manfredini D.
        • Casarosa E.
        • Biondi K.
        • Gabbanini M.
        • Bosco M.
        Sexual hormone serum levels and temporomandibular disorders. A preliminary study.
        Gynecol Endocrinol. 2005; 20: 99-103https://doi.org/10.1080/09513590400021136
        • Peacock A.
        • Alvi N.S.
        • Mushtaq T.
        Period problems: disorders of menstruation in adolescents.
        Arch Dis Child. 2012; 97: 554-560https://doi.org/10.1136/adc.2009.160853
        • Yamashiro T.
        • Takano-Yamamoto T.
        Differential responses of mandibular condyle and femur to estrogen deficiency in young rats.
        Arch Oral Biol. 1998; 43: 191-195https://doi.org/10.1016/S0003-9969(98)00008-9
        • Ahmad N.
        • Chen S.
        • Wang W.
        • Kapila S.
        17β-estradiol induces MMP-9 and MMP-13 in TMJ fibrochondrocytes via estrogen receptor α.
        J Dent Res. 2018; 97: 1023-1030https://doi.org/10.1177/0022034518767108
        • Yu S.
        • Xing X.
        • Liang S.
        • Ma Z.
        • Li F.
        • Wang M.
        • Li Y.
        Locally synthesized estrogen plays an important role in the development of TMD.
        Med Hypotheses. 2009; 72: 720-722https://doi.org/10.1016/j.mehy.2008.11.043
        • Abubaker A.O.
        • Raslan W.F.
        • Sotereanos G.C.
        Estrogen and progesterone receptors in temporomandibular joint discs of symptomatic and asymptomatic persons: a preliminary study.
        J Oral Maxillofac Surg. 1993; 51: 1096-1100https://doi.org/10.1016/S0278-2391(10)80448-3
        • Yamada K.
        • Nozawa-Inoue K.
        • Kawano Y.
        • Kohno S.
        • Amizuka N.
        • Iwanaga T.
        • Maeda T.
        Expression of estrogen receptor α (ERα) in the rat temporomandibular joint.
        Anat Rec A Discov Mol Cell Evol Biol. 2003; 274: 934-941https://doi.org/10.1002/ar.a.10107
        • Wang W.
        • Hayami T.
        • Kapila S.
        Female hormone receptors are differentially expressed in mouse fibrocartilages.
        Osteoarthritis Cartilage. 2009; 17: 646-654https://doi.org/10.1016/j.joca.2008.09.015
        • Chen J.
        • Kamiya Y.
        • Polur I.
        • Xu M.
        • Choi T.
        • Kalajzic Z.
        • Drissi H.
        • Wadhwa S.
        Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth.
        Osteoarthritis Cartilage. 2014; 22: 1861-1868https://doi.org/10.1016/j.joca.2014.07.003
        • Robinson J.L.
        • Cass K.
        • Aronson R.
        • Choi T.
        • Xu M.
        • Buttenbaum R.
        • Drissi H.
        • Lu H.H.
        • Chen J.
        • Wadhwa S.
        Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading.
        Osteoarthritis Cartilage. 2017; 25: 533-543https://doi.org/10.1016/j.joca.2016.11.008
        • Robinson J.L.
        • Gupta V.
        • Soria P.
        • Clanaman E.
        • Gurbarg S.
        • Xu M.
        • Chen J.
        • Wadhwa S.
        Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice.
        Orthod Craniofac Res. 2017; 20: 167-171https://doi.org/10.1111/ocr.12155
        • Robinson J.L.
        • Soria P.
        • Xu M.
        • Vrana M.
        • Luchetti J.
        • Lu H.H.
        • Chen J.
        • Wadhwa S.
        Estrogen promotes mandibular condylar fibrocartilage chondrogenesis and inhibits degeneration via estrogen receptor alpha in female mice.
        Sci Rep. 2018; 8: 1-13https://doi.org/10.1038/s41598-018-26937-w
        • Kamiya Y.
        • Chen J.
        • Xu M.
        • Utreja A.
        • Choi T.
        • Drissi H.
        • Wadhwa S.
        Increased mandibular condylar growth in mice with estrogen receptor beta deficiency.
        J Bone Miner Res. 2013; 28: 1127-1134https://doi.org/10.1002/jbmr.1835
        • Mohamad N.V.
        • Soelaiman I.N.
        • Chin K.Y.
        A concise review of testosterone and bone health.
        Clin Interv Aging. 2016; 11: 1317-1324https://doi.org/10.2147/CIA.S115472
        • Finkelstein J.S.
        • Lee H.
        • Leder B.Z.
        • Burnett-Bowie S.A.
        • Goldstein D.W.
        • Hahn C.W.
        • Hirsch S.C.
        • Linker A.
        • Perros N.
        • Servais A.B.
        • Taylor A.P.
        • Webb M.L.
        • Youngner J.M.
        • Yu E.W.
        Gonadal steroid-dependent effects on bone turnover and bone mineral density in men.
        J Clin Invest. 2016; 126: 1114-1125https://doi.org/10.1172/JCI84137
        • Maor G.
        • Segev Y.
        • Phillip M.
        Testosterone stimulates insulin-like growth factor-I and insulin-like growth factor-I-receptor gene expression in the mandibular condyle—a model of endochondral ossification.
        Endocrinology. 1999; 140: 1901-1910https://doi.org/10.1210/endo.140.4.6618
        • Yuan M.
        • Xie Q.
        • Shen P.
        • Yang C.
        Low skeletal bone mineral density as a potential aetiological factor towards idiopathic condylar resorption.
        Int J Oral Maxillofac Surg. 2020; (S0901-5027(20)30410-0)https://doi.org/10.1016/j.ijom.2020.09.027