Abstract
Adenoid cystic carcinoma (ACC) is a rare salivary gland neoplasm with a poor long-term
prognosis due to multiple recurrences and distant metastatic spread. Circulating tumour
cells (CTCs) are tumour cells shed from a primary, recurrent, or metastatic cancer
that are detectable in the blood or lymphatics. There is no literature to date confirming
the presence of CTCs in ACC. The aim of this study was to determine whether CTCs are
detectable in ACC. Blood samples were collected from eight patients with histologically
confirmed ACC. The TNM stage of the tumour was recorded, as well as any prior treatment.
CTCs were isolated by spiral microfluidics and detected by immunofluorescence staining.
Three of the eight patients recruited (32.5%) had staining consistent with the presence
of CTCs. Of these three patients with detectable CTCs, one had confirmed pulmonary
metastasis, one had suspected pulmonary metastasis and was awaiting confirmation,
and one had local recurrence confirmed on re-resection. One patient with known isolated
pulmonary metastasis had previously undergone a lung metastasectomy and did not have
CTCs detected. CTCs are detectable in ACC. In this small patient sample, CTCs were
found to be present in those patients with recurrent local disease and known distant
metastatic disease. CTCs in ACC should be investigated further for their potential
use as an adjunct in staging, prognosis, and the detection of recurrence.
Keywords
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Article info
Publication history
Published online: December 24, 2020
Accepted:
November 13,
2020
Identification
Copyright
© 2020 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
