Abstract
Temporomandibular joint (TMJ) reconstruction is traditionally invasive. Several investigators
have developed animal models, including mouse models, to study the TMJ. However, there
are no detailed descriptions of a mouse model to be followed for additional research.
The goal of this project was to study minimally invasive TMJ regeneration using tissue
engineering in mice. As part of the project, a detailed mouse model was developed,
which is described in this article. Eight carcasses were used to study the anatomy
of the TMJ of the mouse and 36 mice were used to describe the surgical approach and
perioperative management. The study showed similarities and differences when compared
to humans. One mouse died suddenly 10 days postoperatively, while 35 mice survived
the operation. Keratitis and wound dehiscence were the most common complications.
Investigators reviewing this paper should be able to use this mouse model to further
study TMJ regeneration in mice.
Key words
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Article info
Publication history
Published online: January 13, 2020
Accepted:
December 3,
2019
Identification
Copyright
© 2019 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
