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Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial

  • Author Footnotes
    1 DDS, MSc, PhD student in Maxillofacial Surgery and Trauma. Professor of University of Pernambuco.
    F.S. Landim
    Footnotes
    1 DDS, MSc, PhD student in Maxillofacial Surgery and Trauma. Professor of University of Pernambuco.
    Affiliations
    Maxillofacial Surgery and Trauma, Pernambuco School of Dentistry, University of Pernambuco, Camaragibe, Pernambuco, Brazil
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  • Author Footnotes
    2 PhD, Maxillofacial Surgery and Trauma Professor, University of Pernambuco.
    J.R. Laureano Filho
    Footnotes
    2 PhD, Maxillofacial Surgery and Trauma Professor, University of Pernambuco.
    Affiliations
    Maxillofacial Surgery and Trauma, Pernambuco School of Dentistry, University of Pernambuco, Camaragibe, Pernambuco, Brazil
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  • Author Footnotes
    3 DDS, University of Pernambuco.
    J. Nascimento
    Footnotes
    3 DDS, University of Pernambuco.
    Affiliations
    Maxillofacial Surgery and Trauma, Pernambuco School of Dentistry, University of Pernambuco, Camaragibe, Pernambuco, Brazil
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  • Author Footnotes
    4 PhD, Coordinator of Masters and PhD Programs in Maxillofacial Surgery and Trauma, University of Pernambuco.
    B.C. do Egito Vasconcelos
    Correspondence
    Address: Belmiro Cavalcanti do Egito Vasconcelos, University of Pernambuco, Pernambuco School of Dentistry, Av. General Newton Cavalcante 1650, Camaragibe, Pernambuco, CEP: 54, 756-220, Brazil
    Footnotes
    4 PhD, Coordinator of Masters and PhD Programs in Maxillofacial Surgery and Trauma, University of Pernambuco.
    Affiliations
    Maxillofacial Surgery and Trauma, Pernambuco School of Dentistry, University of Pernambuco, Camaragibe, Pernambuco, Brazil
    Search for articles by this author
  • Author Footnotes
    1 DDS, MSc, PhD student in Maxillofacial Surgery and Trauma. Professor of University of Pernambuco.
    2 PhD, Maxillofacial Surgery and Trauma Professor, University of Pernambuco.
    3 DDS, University of Pernambuco.
    4 PhD, Coordinator of Masters and PhD Programs in Maxillofacial Surgery and Trauma, University of Pernambuco.

      Abstract

      The aim of this study was to evaluate the effectiveness of a nicotine patch for the control of pain, oedema, and trismus following lower third molar surgery. A prospective, randomized, triple-blind, split-mouth trial was performed involving 20 patients who underwent two surgical procedures at different times. A patch containing 14 mg nicotine was used in the experimental group, whereas a patch without nicotine (placebo) was used in the control group. The nicotine patch was effective at controlling pain after 4 hours and 8 hours (P =  0.023 and P =  0.005, respectively). The nicotine patch also had a significant effect on the control of oedema at 24 hours (P =  0.002), 48 hours (P =  0.001), and 72 hours (P =  0.005) following the intervention. Postoperative mouth opening was significantly greater among the patients who received the nicotine patch after 72 hours and 7 days. The number of rescue analgesics required was lower (P =  0.026) and the level of satisfaction was significantly higher (P =  0.008) when the patch was used, although higher levels of nausea were found in the nicotine group (P =  0.031 at 30 minutes, P =  0.008 at 4 hours). The nicotine patch was effective at controlling pain, oedema, and trismus following third molar surgery.

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