Abstract
The aim of this study was to evaluate the effectiveness of a nicotine patch for the
control of pain, oedema, and trismus following lower third molar surgery. A prospective,
randomized, triple-blind, split-mouth trial was performed involving 20 patients who
underwent two surgical procedures at different times. A patch containing 14 mg nicotine was used in the experimental group, whereas a patch without nicotine (placebo)
was used in the control group. The nicotine patch was effective at controlling pain
after 4 hours and 8 hours (P = 0.023 and P = 0.005, respectively). The nicotine patch also had a significant effect on the control
of oedema at 24 hours (P = 0.002), 48 hours (P = 0.001), and 72 hours (P = 0.005) following the intervention. Postoperative mouth opening was significantly
greater among the patients who received the nicotine patch after 72 hours and 7 days.
The number of rescue analgesics required was lower (P = 0.026) and the level of satisfaction was significantly higher (P = 0.008) when the patch was used, although higher levels of nausea were found in the
nicotine group (P = 0.031 at 30 minutes, P = 0.008 at 4 hours). The nicotine patch was effective at controlling pain, oedema,
and trismus following third molar surgery.
Key words
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Article info
Publication history
Published online: May 04, 2020
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© 2019 Published by Elsevier Ltd on behalf of International Association of Oral and Maxillofacial Surgeons.
