Abstract
The purpose of this study was to summarize the currently published cases of clear
cell odontogenic carcinoma (CCOC). The PubMed and Springer databases were used to
collect available reports, searching for ‘clear cell odontogenic carcinoma’, ‘CCOC’,
or ‘clear cell ameloblastoma’. The search resulted in 75 reports detailing 107 cases
between 1985 and 2018. Clinically the tumor manifests as a swelling in the posterior
mandible (n = 46), anterior mandible (n = 33), and maxilla (n = 28). Radiological analysis of 85 cases typically showed a poorly defined expansive
radiolucency (n = 83). Of the 70 patients with symptoms reported, 44 specified a swelling, 11 tooth
mobility, seven gingival/periodontal issues, five numbness, and three decreased jaw
opening. One patient presented with a neck mass. The duration of symptoms prior to
seeking care was specified for 52 patients: 2 months to 1 year for 34 patients, 1–2
years for seven, 2–4 years for two, 4–7 years for six, and 7–12 years for three. The
incidence of recurrence appeared to be 38 of the 88 cases where recurrence was reported.
CCOC can be distinguished from other oral cancers by its distinctive histology and
immunohistochemical characteristics and less aggressive behavior. Currently, treatment
should be early and aggressive resection with clear surgical margins and long-term
follow-up. The overall goal is to collect a cohort of patients.
Key words
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Article info
Publication history
Published online: June 18, 2019
Accepted:
May 22,
2019
Identification
Copyright
© 2019 Published by Elsevier Ltd on behalf of International Association of Oral and Maxillofacial Surgeons.
