Abstract
Osteoarthritis is one of the most frequent pathologies affecting the temporomandibular
joint (TMJ). There is evidence that the use of intra-articular hyaluronic acid (HA)
for the treatment of this disorder achieves positive effects through a reduction in
inflammatory mediators. A systematic review of the available evidence regarding the
regulation of inflammatory mediators when applying HA in osteoarthritis of the TMJ
in humans was performed. The Web of Science, Embase, ScienceDirect, MEDLINE, Scopus,
EBSCOhost, and LILACS databases, SciELO library, and search engine Trip Database were
searched systematically. Two thousand eight hundred and sixty-three related articles
were found, of which only two met the selection criteria (both were clinical trials
and evidence level 2b for treatment studies). These two articles represented a population
of 87 patients. Both articles reported that the application of HA had a positive effect
on the regulation of inflammatory mediators; the mediators studied were those of the
plasminogen activator system and levels of nitric oxide. The limited evidence available
suggests that the application of HA regulates various inflammatory mediators in osteoarthritic
processes in the TMJ. Nevertheless, further evidence in this regard is required, through
the study of specific pathologies of the TMJ, complementing the assessment of clinical
parameters with molecular studies, and generating good quality clinical studies with
larger sample sizes.
Key words
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Article info
Publication history
Published online: February 19, 2017
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© 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
