Abstract
This systematic review aimed to investigate whether intra-articular injections of
hyaluronic acid (HA) are better than other drugs used in temporomandibular joint arthrocentesis,
for the improvement of temporomandibular disorder (TMD) symptoms. Two independent
reviewers performed an electronic search of the MEDLINE and Web of Science databases
for relevant studies published in English up to March 2016. The key words used included
a combination of ‘hyaluronic acid’, ‘viscosupplementation’, ‘intra-articular injections’,
‘corticosteroids’, or ‘non steroidal anti inflammatory agents’ with ‘temporomandibular
disorder’. Selected studies were randomized clinical trials and prospective or retrospective
studies that primarily investigated the application of HA injections compared to other
intra-articular medications for the treatment of TMD. The initial screening yielded
523 articles. After evaluation of the titles and abstracts, eight were selected. Full
texts of these articles were accessed and all fulfilled the inclusion criteria. Intra-articular
injections of HA are beneficial in improving the pain and/or functional symptoms of
TMDs. However, other drug therapies, such as corticosteroid and non-steroidal anti-inflammatory
drug injections, can be used with satisfactory results. Well-designed clinical studies
are necessary to identify an adequate protocol, the number of sessions needed, and
the appropriate molecular weight of HA for use.
Key words
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Article info
Publication history
Published online: June 30, 2016
Accepted:
June 6,
2016
Identification
Copyright
© 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
