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Molecular mechanism of clock genes in tumor microenvironment

      Background: Tumor microenvironment is related to the growth, survival, invasion, and metastasis of the tumor cells. Several studies have proved that stromal fibroblasts (Fibs) have important role in the tumor microenvironment and Fibs convert Cancer-associated fibroblast (CAFs). Clock genes are known to regulate circadian rhythms, angiogenesis, and immunoreaction. Moreover, Clock genes are overexpressed in cancer cells than that in normal cells. Therefore, clock genes should be very important molecules in cancer; however, little has been shown about how these clock genes function in the tumor microenvironment.
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