Effects of nerve growth factor delivery via a collagen/nano-hydroxyapatite gel to mandibular distraction osteogenesis in a rabbit model

      Background and Objectives: There are two concerns in mandibular distraction osteogenesis (DO): the rather long period of treatment and inferior alveolar nerve (IAN) injury. Nerve growth factor (NGF) plays an important role in enhancement recovery of nerve injury and improvement of new bone growth. In this study, we aimed to evaluate the effects of human NGF beta delivery via a collagen/nano-hydroxyapatite/k-carrageenan gel to new bone growth and inferior alveolar nerve histology in the rabbit model of mandibular distraction osteogenesis.
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