Abstract
The aim of this study was to investigate the ability of serrapeptase to reduce postoperative
swelling, pain and trismus after third molar surgery. Twenty-four healthy individuals
with symmetrically impacted mandibular third molars underwent surgical removal in
a prospective, intra-individual, randomized, double-blind, cross-over study. Teeth
were removed in 2 sessions by the same surgeon. At each session, one third molar was
removed under local anaesthesia via a buccal osteotomy. All patients received a combination
of either serrapeptase 5 mg or placebo tablets and 1000 mg paracetamol tablets at either the 1st or 2nd operation in accordance with the randomization
plan. Cheek thickness, pain and interincisal distance were measured preoperatively,
and on the 1st, 2nd, 3rd and 7th postoperative days. Cheek thickness and maximum interincisal
distance were measured using calipers. Pain intensity was assessed clinically using
a numeric scale. There was a significant reduction in the extent of cheek swelling
and pain intensity in the serrapeptase group at the 2nd, 3rd and 7th postoperative
days (P < 0.05), but no significant difference in mean maximal interincisal distance was found
between the 2 groups (P > 0.05).
Keywords
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Article info
Publication history
Published online: February 13, 2008
Accepted:
November 26,
2007
Identification
Copyright
© 2007 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
