Abstract
This study investigated the effect of resveratrol on bone healing and its influence
on the gene expression of osteogenic markers. Two calvarial defects were created and
one screw-shaped titanium implant was inserted in the tibia of rats that were assigned
to daily administration of placebo (control group, n = 15) or 10 mg/kg of resveratrol (RESV group, n = 15) for 30 days. The animals were then sacrificed. One of the calvarial defects was
processed for histomorphometric analysis and the tissue relative to the other was
collected for mRNA quantification of bone morphogenetic protein (BMP)-2, BMP-7, osteopontin
(OPN), bone sialoprotein (BSP), osteoprotegrin (OPG), and receptor activator of NF-κB
ligand (RANKL). Implants were removed by applying a counter-torque force. Histomorphometric
analysis revealed higher remaining defect in the calvarial defects of the control
group than the RESV group (P = 0.026). Resveratrol increased the counter-torque values of implant removal when compared
to control therapy (P = 0.031). Gene expression analysis showed a higher expression of BMP-2 (P = 0.011), BMP-7 (P = 0.049), and OPN (P = 0.002) genes in the RESV group than in the control group. In conclusion, resveratrol
improved the repair of critical-sized bone defects and the biomechanical retention
of implants. Indeed, this natural agent may up-regulate the gene expression of important
osteogenic markers.
Key words
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Article Info
Publication History
Published online: February 18, 2014
Accepted:
January 13,
2014
Identification
Copyright
© 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
