International Journal of Oral & Maxillofacial Surgery
Volume 27, Issue 1 , Pages 67-73, February 1998

Osteopromotive membranes enhance onlay integration and maintenance in the adult rat skull

  • Monica Gordh

      Affiliations

    • Department of Oral Surgery, Centre for Oral Health Sciences, Lund University, Malmö, Sweden
    • Address: Monica Gordh, DMD Department of Oral Surgery Centre for Oral Health Sciences Lund University S-214 21 Malmö Sweden
    • ,
  • Per Alberius

      Affiliations

    • Department of Plastic Surgery, Malmö General Hospital, Malmö, Sweden
    • Department of Oral Biochemistry, Göteborg University, Gothenburg, Sweden
    • ,
  • Olof Johnell

      Affiliations

    • Department of Orthopaedic Surgery, Malmö General Hospital, Malmö, Sweden
    • ,
  • Lisbeth Lindberg

      Affiliations

    • Department of Orthopaedic Surgery, Malmö General Hospital, Malmö, Sweden
    • ,
  • Anders Linde

      Affiliations

    • Department of Oral Biochemistry, Göteborg University, Gothenburg, Sweden

Accepted 10 August 1997.

Article Outline

Abstract 

This study aimed to evaluate the effect of an osteopromotive membrane technique on onlay bone graft survival. Unicortical bone grafts were positioned bilaterally below the temporal muscle in 21 adult Lewis rats. In 14 rats, the bone graft on the right side was covered by an expanded polytetrafluoroethylene GORE-TEX® membrane, whereas that on the left side was left uncovered. Seven rats were killed after 12 (group 1) and 20 (group 2) weeks, respectively. The remaining animals (n=7, group 3) received membranes bilaterally, of which the right-sided membrane was removed after 12 weeks, and these animals were killed after 20 weeks. The specimens were assessed by routine histology and immunohistochemical labelling for various matrix proteins. After 12 weeks (group 1), size differences between the sides were not significant, although all control onlay bone grafts microscopic signs of pronounced resorption. At 20 weeks (group 2), graft integration was more complete on the membrane side. For group 3, the height was significantly more preserved on the side where the membrane was not removed. Immunolabelling demonstrated a more intense bone remodelling at the membrane sites. Membrane treatment resulted in improved graft integration and significantly greater size persistence, but complete height was not maintained.

bone, bone grafts, artificial membrane, polytetrafluoroethylene, rats

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PII: S0901-5027(98)80102-1

International Journal of Oral & Maxillofacial Surgery
Volume 27, Issue 1 , Pages 67-73, February 1998

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