International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 7 , Pages 678-683 , July 2010

Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer

  • S.Y. Lee

      Affiliations

    • Department of Otorhinolaryngology, Chung-Ang University College of Medicine, Seoul, Republic of Korea
    • ,
  • N.H. Cho

      Affiliations

    • Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • E.C. Choi

      Affiliations

    • Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • S.J. Baek

      Affiliations

    • Department of Otorhinolaryngology, Myongji Hospital, Kwandong University College of Medicine, Seoul, Republic of Korea
    • ,
  • W.S. Kim

      Affiliations

    • Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • D.H. Shin

      Affiliations

    • Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • S.-H. Kim

      Affiliations

    • Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationAddress: Se-Heon Kim, Department of Otorhinolaryngology, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, Republic of Korea. 120-752. Tel.: +82 2 2228 3622; fax: +82 2 393 0580.

,Accepted 16 March 2010.

  • Image Result

    Comparison of PCR amplification efficiencies for HPV-16 E2 and E6. A five-point 10-fold series of Caski cell line genomic DNA (2×10−2 to 2×102ng) with amplification efficiencies was found to be very s

    Comparison of PCR amplification efficiencies for HPV-16 E2 and E6. A five-point 10-fold series of Caski cell line genomic DNA (2×10−2 to 2×102ng) with amplification efficiencies was found to be very similar for the two reactions.

  • Image Result
    Representative pathological pictures of HPV-16 positive tongue cancer (a) and HPV-16 negative tongue cancer (b). Pathologically, there was a difference in the invasion characteristics, depending on th

    Representative pathological pictures of HPV-16 positive tongue cancer (a) and HPV-16 negative tongue cancer (b). Pathologically, there was a difference in the invasion characteristics, depending on the presence of HPV-16 infection. 67% of HPV-16 positive cancer showed pushing margin and less infiltrative pattern. On the contrary, 57% of HPV-16 negative cancer showed infiltrative margins.

  • Image Result
    Comparison of invasion depths according to HPV-16 infection in oral tongue cancer. The ratio of vertical invasion to the horizontal width was significantly low in the HPV-16 positive group (p=0.045).

    Comparison of invasion depths according to HPV-16 infection in oral tongue cancer. The ratio of vertical invasion to the horizontal width was significantly low in the HPV-16 positive group (p=0.045).

  • Image Result
    Comparison of tumour-specific survival according to HPV-16 infection. The HPV-16 positive group showed favourable disease-specific survival (p=0.24).

    Comparison of tumour-specific survival according to HPV-16 infection. The HPV-16 positive group showed favourable disease-specific survival (p=0.24).

PII: S0901-5027(10)00108-6

doi: 10.1016/j.ijom.2010.03.014

International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 7 , Pages 678-683 , July 2010

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