International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 7 , Pages 705-712 , July 2010

Cyanoacrylate in nerve repair: transient cytotoxic effect

  • T. Landegren

      Affiliations

    • Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Section of Hand Surgery, Sweden
    • Corresponding Author InformationAddress: Thomas Landegren, Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Section of Hand Surgery, SE-118 83 Södersjukhuset, Stockholm, Sweden. Tel.: +46 86 16 20 41; fax: +46 884 65 99.
  • ,
  • M. Risling

      Affiliations

    • Department of Neuroscience, Experimental Traumatology Unit, Retzius Laboratory, Karolinska Institutet, Sweden
  • ,
  • J.K.E. Persson

      Affiliations

    • Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Universitetssjukhuset Solna, Sweden
  • ,
  • A. Sondén

      Affiliations

    • Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Section of Surgery, Stockholm, Sweden

,Accepted 16 March 2010.

References 

  1. Administration TUFaD . Treatment news bulletin. Curr Treat Options Neurol. 2001;3:1–5
  2. Alio JL, Gomez J, Mulet E, Bujanda MM, Martinez JM, Molina Y. A new acrylic tissue adhesive for conjunctival surgery: experimental study. Ophthal Res. 2003;35:306–312
  3. Ang ES, Tan KC, Tan LH, Ng RT, Song IC. 2-Octylcyanoacrylate-assisted microvascular anastomosis: comparison with a conventional suture technique in rat femoral arteries. J Reconstr Microsurg. 2001;17:193–201
  4. Bertelli JA, Mira JC. Nerve repair using freezing and fibrin glue: immediate histologic improvement of axonal coaptation. Microsurgery. 1993;14:135–140
  5. Bratt J, Lerner R, Ringertz B, Palmblad J. Lipoxin A4 induces neutrophil-dependent cytotoxicity for human endothelial cells. Scand J Immunol. 1994;39:351–354
  6. Brunner KT, Mauel J, Cerottini JC, Chapuis B. Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunology. 1968;14:181–196
  7. Cao Z, Hallur S, Qiu HZ, Peng X, Li Y. Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity. Biochem Biophys Res Commun. 2004;316:1043–1049
  8. Choi BH, Kim BY, Huh JY, Lee SH, Zhu SJ, Jung JH, et al. Microneural anastomosis using cyanoacrylate adhesives. Int J Oral Maxillofac Surg. 2004;33:777–780
  9. Chopra J, Joist JH, Webster RO. Loss of 51chromium, lactate dehydrogenase, and 111indium as indicators of endothelial cell injury. Lab Invest. 1987;57:578–584
  10. Ciapetti G, Stea S, Cenni E, Sudanese A, Marraro D, Toni A, et al. Cytotoxicity testing of cyanoacrylates using direct contact assay on cell cultures. Biomaterials. 1994;15:63–67
  11. de Azevedo CL, Marques MM, Bombana AC. Cytotoxic effects of cyanoacrylates used as retrograde filling materials: an in vitro analysis. Pesqui Odontol Bras. 2003;17:113–118
  12. DeJongh J, Nordin-Andersson M, Ploeger BA, Forsby A. Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations. Toxicol Appl Pharmacol. 1999;158:261–268
  13. Faldini A, Puntoni P, Magherini PC, Lisanti M, Carlucci F, Risaliti R. Comparative neurophysiological assessments of nerve sutures performed by microsurgical methods and with fibrin glue: experimental study. Ital J Orthop Traumatol. 1984;10:527–532
  14. Jackson MR. Fibrin sealants in surgical practice: an overview. Am J Surg. 2001;182:1S–7S
  15. Javelet J, Torabinejad M, Danforth R. Isobutyl cyanoacrylate: a clinical and histologic comparison with sutures in closing mucosal incisions in monkeys. Oral Surg Oral Med Oral Pathol. 1985;59:91–94
  16. Landegren T, Risling M, Brage A, Persson JK. Long-term results of peripheral nerve repair: a comparison of nerve anastomosis with ethyl-cyanoacrylate and epineural sutures. Scand J Plast Reconstr Surg Hand Surg. 2006;40:65–72
  17. Landegren T, Risling M, Persson JK. Local tissue reactions after nerve repair with ethyl-cyanoacrylate compared with epineural sutures. Scand J Plast Reconstr Surg Hand Surg. 2007;41:217–227
  18. Maragh H, Meyer BS, Davenport D, Gould JD, Terzis JK. Morphofunctional evaluation of fibrin glue versus microsuture nerve repairs. J Reconstr Microsurg. 1990;6:331–337
  19. Millesi H. Peripheral nerve surgery today: turning point or continuous development?. J Hand Surg [Br]. 1990;15:281–287
  20. Miyauchi A, Kanje M, Danielsen N, Dahlin LB. Role of macrophages in the stimulation and regeneration of sensory nerves by transposed granulation tissue and temporal aspects of the response. Scand J Plast Reconstr Surg Hand Surg. 1997;31:17–23
  21. Narakas A. The use of fibrin glue in repair of peripheral nerves. Orthop Clin North Am. 1988;19:187–199
  22. Nordin-Andersson M, Walum E, Kjellstrand P, Forsby A. Acrylamide-induced effects on general and neurospecific cellular functions during exposure and recovery. Cell Biol Toxicol. 2003;19:43–51
  23. Perry VH, Brown MC. Role of macrophages in peripheral nerve degeneration and repair. Bioessays. 1992;14:401–406
  24. Smahel J, Meyer VE, Bachem U. Glueing of peripheral nerves with fibrin: experimental studies. J Reconstr Microsurg. 1987;3:211–220
  25. Suri A, Mehta VS, Sarkar C. Microneural anastomosis with fibrin glue: an experimental study. Neurol India. 2002;50:23–26
  26. Tetik C, Ozer K, Ayhan S, Siemionow K, Browne E, Siemionow M. Conventional versus epineural sleeve neurorrhaphy technique: functional and histomorphometric analysis. Ann Plast Surg. 2002;49:397–403
  27. Thumwanit V, Kedjarune U. Cytotoxicity of polymerized commercial cyanoacrylate adhesive on cultured human oral fibroblasts. Aust Dent J. 1999;44:248–252
  28. Toriumi DM, Raslan WF, Friedman M, Tardy ME. Histotoxicity of cyanoacrylate tissue adhesives. A comparative study. Arch Otolaryngol Head Neck Surg. 1990;116:546–550
  29. Tseng YC, Hyon SH, Ikada Y, Shimizu Y, Tamura K, Hitomi S. In vivo evaluation of 2-cyanoacrylates as surgical adhesives. J Appl Biomater. 1990;1:111–119
  30. Tseng YC, Tabata Y, Hyon SH, Ikada Y. In vitro toxicity test of 2-cyanoacrylate polymers by cell culture method. J Biomed Mater Res. 1990;24:1355–1367
  31. Valen G, Sonden A, Vaage J, Malm E, Kjellstrom BT. Hydrogen peroxide induces endothelial cell atypia and cytoskeleton depolymerization. Free Radic Biol Med. 1999;26:1480–1488
  32. Wieken K, Angioi-Duprez K, Lim A, Marchal L, Merle M. Nerve anastomosis with glue: comparative histologic study of fibrin and cyanoacrylate glue. J Reconstr Microsurg. 2003;19:17–20

PII: S0901-5027(10)00101-3

doi: 10.1016/j.ijom.2010.03.008

International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 7 , Pages 705-712 , July 2010