International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 7 , Pages 647-652 , July 2010

Preemptive effect of ketoprofen on postoperative pain following third molar surgery. A prospective, randomized, double-blinded clinical trial

  • T. Kaczmarzyk

      Affiliations

    • Department of Oral Surgery, Jagiellonian University Medical College, Krakow, Poland
    • Corresponding Author InformationAddress: Tomasz Kaczmarzyk, Department of Oral Surgery, Jagiellonian University Medical College, Montelupich 4, 31-155 Krakow, Poland. Tel.: +48 12 4245468; fax: +48 12 4245499.
    web address
    • ,
  • J. Wichlinski

      Affiliations

    • Department of Oral Surgery, Jagiellonian University Medical College, Krakow, Poland
    • ,
  • J. Stypulkowska

      Affiliations

    • Department of Oral Surgery, Jagiellonian University Medical College, Krakow, Poland
    • ,
  • M. Zaleska

      Affiliations

    • Department of Oral Surgery, Jagiellonian University Medical College, Krakow, Poland
    • ,
  • J. Woron

      Affiliations

    • Department of Clinical Pharmacology, Jagiellonian University Medical College, Krakow, Poland

,Accepted 9 February 2010.

References 

  1. Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med. 2001;134:663–694
  2. Beilin B, Bessler H, Mayburd E, Smirnov G, Dekel A, Yardeni I. Effect of preemptive analgesia on pain and cytokine production in the postoperative period. Anesthesiology. 2003;98:151–155
  3. Birrell GJ, McQueen DS, Iggo A, Coleman RA, Grubb BD. PGI2-induced activation and sensitization of articular mechanonociceptors. Neurosci Lett. 1991;124:5–8
  4. Bjørnsson GA, Haanaes HR, Skoglund LA. Ketoprofen 75mg qid versus acetaminophen 1000mg qid for 3 days on swelling, pain, and other postoperative events after third-molar surgery. J Clin Pharmacol. 2003;43:305–314
  5. Bridgman JB, Gillgrass TG, Zacharias M. The absence of any pre-emptive analgesic effect for non-steroidal anti-inflammatory drugs. Br J Oral Maxillofac Surg. 1996;34:428–431
  6. Campbell WI, Kendrick RW, Patterson C. Intravenous diclofenac sodium. Does its administration before operation suppress postoperative pain?. Anaesthesia. 1990;45:763–766
  7. Campbell WI, Kendrick RW, Fee JPH. Balanced pre-emptive analgesia: does it work? A double-blind, controlled study in bilaterally symmetrical oral surgery. Br J Anaesth. 1998;81:727–730
  8. Daniels SE, Desjardins PJ, Talwalker S, Recker DP, Verburg KM. The analgesic efficacy of valdecoxib vs. oxycodone/acetaminophen after oral surgery. J Am Dent Assoc. 2002;133:611–621
  9. Desjardins PJ, Grossman EH, Kuss ME, Talwalker S, Dhadda S, Baum D. The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively. Anesth Analg. 2001;93:721–727
  10. Dray A. Inflammatory mediators of pain. Br J Anaesth. 1995;75:125–131
  11. Helmy SA, Bali A. The effect of the preemptive use of the NMDA receptor antagonist dextromethorphan on postoperative analgesic requirements. Anesth Analg. 2001;92:739–744
  12. Hill CM, Carroll MJ, Giles AD, Pickvance N. Ibuprofen given pre- and post-operatively for the relief of pain. Int J Oral Maxillofac Surg. 1987;16:420–424
  13. Hutchison GL, Crofts SL, Gray IG. Preoperative piroxicam for postoperative analgesia in dental surgery. Br J Anaesth. 1990;65:500–503
  14. Joshi A, Parara E, Macfarlane TV. A double-blind randomised controlled clinical trial of the effect of preoperative ibuprofen, diclofenac, paracetamol with codeine and placebo tablets for relief of postoperative pain after removal of impacted third molars. Br J Oral Maxillofac Surg. 2004;42:299–306
  15. Jung YS, Kim MK, Um YJ, Park HS, Lee EW, Kang JW. The effects on postoperative oral surgery pain by varying NSAID administration times: comparison on effect of preemptive analgesia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:559–563
  16. Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia. I. Physiological pathways and pharmacological modalities. Can J Anesth. 2001;48:1000–1010
  17. Kissin I. Preemptive analgesia. Anesthesiology. 2000;93:1138–1143
  18. Kitahata LM. Pain pathways and transmission. Yale J Biol Med. 1993;66:437–442
  19. Lebrun T, Van Elstraete AC, Sandefo I, Polin B, Pierre-Louis L. Lack of pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery. Can J Anesth. 2006;53:146–152
  20. Lynn B. Neurogenic inflammation. Skin Pharmcol. 1988;1:217–224
  21. Marković AB, Todorović L. Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:e4–e8
  22. Moore PA, Brar P, Smiga ER, Costello BJ. Preemptive rofecoxib and dexamethasone for prevention of pain and trismus following third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:e1–e7
  23. Nenman MC, Leach GD, Naylor IL. Production of prostaglandin-like materials by rat tail skin in response to injury. Br J Pharmacol. 1979;66:448
  24. Olmedo MV, Gálvez R, Vallecillo M. Double-blind parallel comparison of multiple doses of ketorolac, ketoprofen and placebo administered orally to patients with postoperative dental pain. Pain. 2001;90:135–141
  25. Ong KS, Seymour RA, Chen FG, Ho VCL. Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. Int J Oral Maxillofac. 2004;33:771–776
  26. Ong CKS, Lirk P, Seymour RA, Jenkins BJ. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesth Analg. 2005;100:757–773
  27. Pozos-Guillen A, Martinez-Rider R, Aguirre-Banuelos P, Perer-Urizar J. Pre-emptive analgesic effect of tramadol after mandibular third molar extraction: a pilot study. J Oral Maxillofac Surg. 2007;65:1315–1320
  28. Primosch RE, Nichols DL, Courts FJ. Comparison of preoperative ibuprofen, acetaminophen, and placebo administration on the parental report of postextraction pain in children. Pediatr Dent. 1995;17:187–191
  29. Savage MG, Henry MA. Preoperative nonsteroidal anti-inflammatory agents: review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:146–152
  30. Selcuk E, Gomel M, Apaydin S, Kose T, Tuglular I. The postoperative analgesic efficacy and safety of piroxicam (FDDF) and naproxen sodium. Int J Clin Pharmacol Res. 1998;18:21–29
  31. Seymour RA, Meechan JG, Blair GS. An investigation into postoperative pain after third molar surgery under local analgesia. Br J Oral Maxillofac Surg. 1985;23:410–418
  32. Seymour RA, Kelly PJ, Hawkesford JE. Pharmacokinetics and efficacy of low-dose ketoprofen in postoperative dental pain. Clin Drug Investig. 1998;15:279–284
  33. Sisk AL, Grover BJ. A comparison of preoperative and postoperative naproxen sodium for suppression of postoperative pain. J Oral Maxillofac Surg. 1990;48:674–678
  34. Sisk AL, Mosley RO, Martin RP. Comparison of preoperative and postoperative diflunisal for suppression of postoperative pain. J Oral Maxillofac Surg. 1989;47:464–468
  35. Sunshine A, Olson NZ, Marrero I, Tirado S. Onset and duration of analgesia for low-dose ketoprofen in the treatment of postoperative dental pain. J Clin Pharmcol. 1998;38:1155–1164
  36. Taylor BK, Brennan TJ. Preemptive analgesia: moving beyond conventional strategies and confusing terminology. J Pain Symptom Manage. 2000;1:77–84
  37. Vanegas H, Schaible HG. Prostaglandins and cyclooxygenases in the spinal cord. Prog Neurobiol. 2001;64:327–363
  38. Vogel RI, Desjardins PJ, Major KV. Comparison of presurgical and immediate postsurgical ibuprofen on postoperative periodontal pain. J Periodontol. 1992;63:914–918
  39. Walker K, Perkins M, Dray A. Kinins and kinin receptors in the nervous system. Neurochem Int. 1995;26:17–26

PII: S0901-5027(10)00064-0

doi: 10.1016/j.ijom.2010.02.019

International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 7 , Pages 647-652 , July 2010

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