International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 4 , Pages 371-378 , April 2010

The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss®: an experimental study in goats

  • R.E.C.M. Mooren

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationAddress: Robert E.C.M. Mooren, Geert Groote plein 14, Nijmegen, 6500 HB, The Netherlands. Tel.: +00 31 26 8444543.
    • ,
  • A.C.A. Dankers

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • M.A.W. Merkx

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • E.M. Bronkhorst

      Affiliations

    • Department of Preventive and Operative Dentistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • J.A. Jansen

      Affiliations

    • Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • P.J.W. Stoelinga

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

,Accepted 23 December 2009.

References 

  1. Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study. J Oral Maxillofac Surg. 2002;60:1176–1181
  2. Berglundh T, Lindhe J. Healing around implants placed in bone defects treated with Bio-Oss. An experimental study in the dog. Clin Oral Implants Res. 1997;8:117–124
  3. Botticelli D, Berglundh T, Lindhe J. The influence of a biomaterial on the closure of a marginal hard tissue defect adjacent to implants. An experimental study in the dog. Clin Oral Implants Res. 2004;15:285–292
  4. Choi BH, Im JY, Suh JJ, Lee SH. Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. Int J Oral Maxillofac Surg. 2004;33:56–59
  5. Clemmons RM, Bliss EL, Dorsey-Lee MR, Seachord CL, Meyers KM. Platelet function, size and yield in whole blood and in platelet-rich plasma prepared using differing centrifugation force and time in domestic and food producing animals. Thromb Haemost. 1983;50:838–843
  6. Clergeau LP, Danan M, Clergeau-Guerithault S, Brion M. Healing response to anorganic bone implantation in periodontal intrabony defects in dogs. Part I. Bone regeneration. A microradiographic study. J Periodontol. 1996;67:140–149
  7. Fennis JPM, Stoelinga PJW, Jansen JA. Mandibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffolds, particulate cortico-cancellous bone grafts and platelet-rich plasma in goats. Int J Oral Maxillofac Surg. 2004;33:48–55
  8. Fukuta K, Har-Shai Y, Collares MV, Lichten JB, Jackson IT. Comparison of inorganic bovine bone mineral particles with porous hydroxyapatite granules and cranial bone dust in the reconstruction of full-thickness skull defect. J Craniofac Surg. 1992;3:25–29
  9. Galindo-Moreno P, Avila G, Fernández-Barbero JE, Aguilar M, Sánchez-Fernández E, Cutando A, et al. Evaluation of sinus floor elevation using a composite bone graft mixture. Clin Oral Implants Res. 2007;18:376–382
  10. Hämmerle CH, Olah AJ, Schmid J, Flückiger L, Gogolewski S, Winkler JR, et al. The biological effect of natural bone mineral on bone neoformation on the rabbit skull. Clin Oral Implants Res. 1997;8:198–207
  11. Hedberg EL, Kroese-Deutman HC, Shih CK, Lemoine JJ, Liebschner MA, Miller MJ, et al. Methods, a comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering. Tissue Eng. 2005;11:1356–1367
  12. Jensen SS, Aaboe M, Pinholt EM, Hjørting-Hansen E, Melsen F, Ruyter IE. Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants. 1996;11:55–66
  13. Kim ES, Park EJ, Choung PH. Platelet concentration and its effect on bone formation in calvarial defects, an experimental study in rabbits. J Prosthet Dent. 2001;86:428–433
  14. Kim SG, Chung CH, Kim YK, Park JC, Lim SC. Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants. Int J Oral Maxillofac Implants. 2002;17:86–94
  15. Lubbe van der HB, Klein CP, Groot de K. A simple method for preparing thin (10microM) histological sections of undecalcified plastic embedded bone with implants. Stain Technol. 1988;63:171–175
  16. Marx RE. Platelet-rich plasma growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Radiol Endod. 1998;85:638–646
  17. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62:489–496
  18. Merck & Co. Veterinary Manual 2006: Table 6 Hematologic references ranges.
  19. Merkx MAW, Fennis JPM, Verhagen CM, Stoelinga PJW. Reconstruction of the mandible using preshaped 2.3mm titanium plates, autogenous particulate cortico-cancellous bone grafts and platelet-rich plasma: a report on eight patients. Int J Oral Maxillofac Surg. 2004;33:733–739
  20. Merkx MAW, Maltha JC, Freihofer HPM, Kuijpers-Jagtman AM. Incorporation of three types of bone block grafts in the facial skeleton. Biomaterials. 1999;20:639–645
  21. Merkx MAW, Maltha JC, Freihofer HPM, Kuijpers-Jagtman AM. Incorporation of particulate bone grafts in the facial skeleton. Biomaterials. 1999;20:2029–2035
  22. Mooren RECM, Hendriks EJ, van den Beucken JJJP, Merkx MAW, Meijer GJ, Jansen JA, Stoelinga PJW. The effect of platelet-rich plasma in vitro on primary cells: rat osteoblast-like cells and human endothelium cells. Tissue Engineering, submitted for publication.
  23. Mooren RECM, Merkx MAW, Bronkhorst EM, Jansen JA, Stoelinga PJW. The effect of platelet-rich plasma on early and late bone healing: an experimental study in goats. Int J Oral Maxillofac Surg. 2007;36:626–631
  24. Peetz M. Characterisation of xenogenic bone material. In:  Boyne PJ editors. Osseous Reconstruction of the Maxilla and Mandibula: Surgical Techniques Using Titanium Mesh and Bone Mineral. Carol Stream, IL: Quintessence; 1997;p. 87–100
  25. Piattelli M, Favero GA, Scarano A, Orsini G, Piattelli A. Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans. Int J Oral Maxillofac Implants. 1999;14:835–840
  26. Pietersz RN, de Korte D, Reesink HW, Dekker WJ, van den Ende A, Loos JA. Storage of whole blood for up to 24hours at ambient temperature prior to component preparation. Vox Sang. 1989;56:145–150
  27. Plachokova AS, van den Dolder J, Stoelinga PJ, Jansen JA. Early effect of platelet-rich plasma on bone healing in combination with an osteoconductive material in rat cranial defects. Clin Oral Implants Res. 2007;18:244–251
  28. Plachokova AS, van den Dolder J, van den Beucken JJ, Jansen JA. Bone regenerative properties of rat, goat and human platelet-rich plasma. Int J Oral Maxillofac Surg. 2009;38:861–869
  29. Polyzois I, Renvert S, Bosshardt DD, Lang NP, Claffey N. Effect of Bio-Oss on osseointegration of dental implants surrounded by circumferential bone defects of different dimensions, an experimental study in the dog. Clin Oral Implants Res. 2007;18:304–310
  30. Sanz C, Pereira A, Vila J, Faundez AI, Gomez J, Ordinas A. Growth of bacteria in platelet concentrates obtained from whole blood stored for 16hours at 22 degrees C before component preparation. Transfusion. 1997;37(March):251–254
  31. Satow S, Slagter AP, Stoelinga PJW, Habets LL. Interposed bone grafts to accommodate endosteal implants for retaining mandibular overdentures. A 1–7 year follow-up study. Int J Oral Maxillofac Surg. 1997;26:358–364
  32. Schlegel KA, Donath K, Rupprecht S, Falk S, Zimmerman R, Felszeghy E, et al. De novo bone formation using bovine collagen and platelet-rich plasma. Biomaterials. 2004;25:5387–5393
  33. Schlegel KA, Kloss FR, Kessler P, Schultze-Mosgau S, Nkenke E, Wiltfang J. Bone conditioning to enhance implant osseointegration: an experimental study in pigs. Int J Oral Maxillofac Implants. 2003;18:505–511
  34. Simon EN, Merkx MAW, Shubi FM, Kalyanyama BM, Stoelinga PJW. Reconstruction of the mandible after ablative surgery for the treatment of aggressive, benign odontogenic tumours in Tanzania: a preliminary study. Int J Oral Maxillofac Surg. 2006;35:421–426
  35. Tayaponsak PJ, O’Brien DA, Monteiro CB, Arceo Diaz LL. Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg. 1994;52:161–166
  36. Thorn JJ, Sørensen H, Weis-Fogh U, Andersen M. Autologous fibrin glue with growth factors in reconstructive maxillofacial surgery. Int J Oral Maxillofac Surg. 2004;33:95–100
  37. Thorwarth M, Wehrhan F, Schultze-Mosgau S, Wiltfang J, Schlegel KA. PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation. Bone. 2006;38:30–40
  38. Valentini P, Abensur D, Wenz B, Peetz M, Schenk R. Sinus grafting with porous bone mineral (Bio-Oss) for implant placement: a 5-year study on 15 patients. Int J Periodontics Restorative Dent. 2000;20:245–253
  39. Wetzel AC, Stich H, Caffesse RG. Bone apposition onto oral implants in the sinus area filled with different grafting materials. A histological study in beagle dogs. Clin Oral Implants Res. 1995;6:155–163
  40. Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmerman R, et al. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. Clin Oral Implants Res. 2004;15:187–193
  41. Yu JC, McClintock JS, Gannon F, Gao XX, Mobasser JP, Sharawy M. Regional differences of dura osteoinduction: squamous dura induces osteogenesis, sutural dura induces chondrogenesis and osteogenesis. Plast Reconstr Surg. 1997;100:23–31
  42. Zechner W, Tangl S, Tepper G, Fürst G, Bernhart T, Haas R, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic an histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18:15–22
  43. Zins JE, Kusiak JF, Whitaker LA, Enlow DH. The influence of the recipient site on bone grafts to the face. Plast Reconstr Surg. 1984;73:371–381

PII: S0901-5027(09)01226-0

doi: 10.1016/j.ijom.2009.12.019

International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 4 , Pages 371-378 , April 2010

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