The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss®: an experimental study in goats

Mooren, R.E.C.M.; Dankers, A.C.A.; Merkx, M.A.W.; Bronkhorst, E.M.; Jansen, J.A.; Stoelinga, P.J.W.

doi:10.1016/j.ijom.2009.12.019

« Previous Next »International Journal of Oral & Maxillofacial Surgery
Volume 39, Issue 4 , Pages 371-378, April 2010

The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss^®: an experimental study in goats

R.E.C.M. Mooren
- Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
- Address: Robert E.C.M. Mooren, Geert Groote plein 14, Nijmegen, 6500 HB, The Netherlands. Tel.: +00 31 26 8444543.
A.C.A. Dankers
- Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
M.A.W. Merkx
- Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
E.M. Bronkhorst
- Department of Preventive and Operative Dentistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J.A. Jansen
- Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
P.J.W. Stoelinga
- Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Accepted 23 December 2009. published online 03 February 2010.

Abstract

Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss^®) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss^®) particles, in which 1ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used.